Studies have shown that individuals with endocrine metabolic disorders that can be explained by genetic and environmental influences are at increased risk of depression.
“Depression is common in people with endocrine and metabolic disorders and vice versa, and there is a need to better understand the underlying factors that contribute to the comorbidities of these disorders,” said the authors. .
A population-based cohort study of 2.2 million people was conducted in Sweden between 1973 and 1996, followed up to 2013. Brother.
Next, the authors evaluated the diagnosis of depression and endocrine-metabolic status, comparing the latter to autoimmune diseases (autoimmune hypothyroidism, Graves’ disease, and type 1 diabetes) and non-autoimmune diseases (type 2 diabetes). , obesity, and polycystic ovary syndrome).
Logistic regression and Cox regression were used to estimate the association between endocrine metabolic disorders and depression within the same individual and between siblings. The relative contributions of genetic and environmental factors were also examined using quantitative genetic modeling.
People with endocrine metabolism disorders had a significantly higher risk of depression, odds ratio 1.43 (95% confidence interval) [CI], 1.30–1.57) to 3.48 (95% CI, 3.25–3.72) in type 2 diabetes. This increased risk extended to full and half siblings.
The association between depression risk and endocrine metabolic disorders was driven by common genetic influences for non-autoimmune diseases and non-common environmental factors for autoimmune diseases, especially type 1 diabetes.
“These findings provide phenotypic and etiological insights into the co-occurrence of depression and various endocrine-metabolic states and may guide future studies aimed at identifying pathophysiological mechanisms and intervention targets.” There is,” said the authors.
